Thioredoxin-mediated Denitrosylation Regulates Cytokine-induced Nuclear Factor κB (NF-κB) Activation
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چکیده
منابع مشابه
Hyperglycemia- Induced NF-κB Activation Increases microRNA-146a Expression in Human Umbilical Vein Endothelial Cells
Background & objectives: Nuclear Factor kappa B (NF-κB), a master switch transcription factor, plays a critical role in the progression and development of hyperglycemia-induced microangiopathy. Hyperglycemia activates NF-κB, and subsequently increases pro-inflammatory cytokines such as TNF-α, IL-6 and IL-1β leading to development of inflammation. Some new studies have revealed the involvement o...
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3 4 Authors: Steven K. Malin1,2, John P. Kirwan1,2, Chang Ling Sia3, and Frank González3 5 6 7 1Dept. of Pathobiology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH; 8 2Dept. of Nutrition, School of Medicine, Case Western Reserve University, Cleveland, OH; 9 3Dept. of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN. 10 11 12 13 14 Funding: Nationa...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2014
ISSN: 0021-9258
DOI: 10.1074/jbc.m113.503938